Current Issue : January - March Volume : 2020 Issue Number : 1 Articles : 5 Articles
Pogostemon benghalensis leaves have traditionally been utilized for relieving\nbody aches, headaches and fever. Based on its uses, the present study was designed to investigate the\nantinociceptive, antipyretic and anti-edematogenic activities from P. benghalensis leavesâ?? methanol\nextract (PBME) inWister rats. Methods: The thermal (hot plate) and chemical (acetic acid-induced\nwrithing and formalin test) models for antinociceptive effects, and the Brewerâ??s yeast induced\nhyperthermia test for antipyretic action and rat paw edema by carrageenan for anti-edematogenic\nactivity, were applied for PBME at different dose levels. The acute toxicity of PBME through the oral\nroute was performed to determine the lethal dose. Results: PBME significantly and dose-dependently\nreduced pyrexia and diminished edema volume, which depicted its antipyretic and anti-edematogenic\neffects respectively. The inhibition of writhing reflex, increased reaction latency and reduced frequency\nof licking indicated that PBME has significant dose-dependent antinociceptive activity. P. benghalensis\nmethanol extract at 4000 mg/kg shows no sign of toxicity, which is a considerable, good margin of\nsafety. Conclusions: The study illustrated the antipyretic, antinociceptive and anti-inflammatory\npotential of P. benghalensis leaf extract with a safety margin, and validated its traditional use to\nalleviate fever, pain, and inflammation....
Drug resistance remains a major challenge in the treatment of cancer. The multiplicity\nof the drug resistance determinants raises the question about the optimal strategies to deal with\nthem. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain\nseveral chemical classes of compounds whose heterogeneity of active moieties can help prevent the\ndevelopment of drug resistance. In the present paper, we analyzed, by gas chromatography-mass\nspectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis\nobtained by hydrodistillation and compared the chemical composition of its essential oil with that\nof Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both\nspecies against acute myeloid leukemia on an in vitro model and its multidrug resistant variant\ninvolving�����....
Dipterocarpus alatus (Dipterocarpaceae) is a medicinal plant whose use is well known for\nthe treatment of genito-urinary diseases. However, there is no report of its cytotoxic potential. In this\nstudy, the chemical composition, antioxidant and cytotoxic activities of extracts of the leaves, bark,\ntwigs and oleo-resin from D. alatus are investigated. Cytotoxicity was measured by the neutral red\n(NR) assay against HCT116, SKLU1, SK-MEL2, SiHa and U937 cancer cell lines and antioxidant\ncapacity was evaluated by DPPH, ABTS radical scavenging, and ferric reducing antioxidant power\n(FRAP) assays. The chemical composition was analyzed by gas chromatography-mass spectrometry\n(GC-MS). Leaf, bark and twig extracts exhibited stronger antioxidant activity than oleo-resin, with bark\nextract showing the highest antioxidant activity and the highest total phenolic content. All samples\nshowed more cytotoxic activity against the U937 cell line than HCT116, SKLU1, SK-MEL2 and SiHa\ncells with oleo-resin being more cytotoxic than melphalan against U937 cells. Chemical composition\nanalysis of oleo-resin by GC-MS showed that the major components were sesquiterpenes, namely�����...
Nano-sized metals have been introduced as a promising solution for microbial resistance to\nantimicrobial agents. Silver nanoparticles (AgNPs) have been proven to possess good antimicrobial\nactivity. Green synthesis of AgNPs has been reported as safe, low cost and ecofriendly. This\nmethodology uses extracts originating from different plants to reduce silver ions from AgNO3 into\nnano-sized particles. In this study, extracts of several plants including ginger, garlic, capsicum and\ntheir mixtures were successfully used to produce AgNPs. Numerous spectroscopic, light scattering\nand microscopic techniques were employed to characterize the synthesized AgNPs. Agar well\ndiffusion assay was performed to investigate the antimicrobial activity of AgNPs. The biosynthesized\nAgNPs have spherical shape with a size range of 20-70 nm. Garlic extract, pure or in mixture with\nginger extract, generated AgNPs of the smallest size. The presence of the plant-origin capping\nagents surrounding AgNPs was proven by Fourier-transform infrared spectroscopy. The AgNPs, at a\nconcentration of 50 microg/mL, demonstrated potent antimicrobial activity against Staphyloccocus aureus,\nEscherichia coli and Candida albicans as indicated by the zones of inhibitions. Our results revealed that\nAgNPs having potent antimicrobial activity could be prepared using different pure plant extracts and\ntheir mixtures....
Clausena lansium Lour. Skeels (Rutaceae) is widely distributed in South China and has\nhistorically been used as a traditional medicine in local healthcare systems. Although the characteristic\ncomponents (carbazole alkaloids and coumarins) of C. lansium have been found to possess a wide\nvariety of biological activities, little attention has been paid toward the other components of this plant.\nIn the current study, phytochemical analysis of isolates from a water-soluble stem and leaf extract\nof C. lansium led to the identification of 12 compounds, including five aromatic glycosides, four\nsesquiterpene glycosides, two dihydrofuranocoumarin glycosides, and one adenosine. All compounds\nwere isolated for the first time from the genus Clausena, including a new aromatic glycoside (1),\na new dihydrofuranocoumarin glycoside (6), and two new sesquiterpene glycosides (8 and 9).\nThe phytochemical structures of the isolates were elucidated using spectroscopic analyses including\nNMRand MS. The existence of these compounds demonstrates the taxonomic significance of C. lansium\nin the genus Clausena and suggests that some glycosides from this plant probably play a role in the\nanticancer activity of C. lansium to some extent�����....
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